A major challenge raised by the Human Genome Project is how to translate its extraordinary information content into health benefits. An impediment to achieving this goal relates to the shortage of physicians who are well trained in both medicine and genetics. The BWH Combined Residency in Genetics, a component of the BWH Internal Medicine Residency Program, aims to address this problem by training carefully selected BWH Internal Medicine Housestaff in both Internal Medicine and Medical Genetics. The primary goal of these two Programs is to train physicians and physician-scientists who will become leaders in Genomics, and who will help catalyze the introduction of genetics into the care of adult patients.