Combined Residency in Genetics and Medicine

A major challenge raised by the Human Genome Project is how to translate its extraordinary information content into health benefits. An impediment to achieving this goal relates to the shortage of physicians who are well trained in both medicine and genetics. The BWH Combined Residency in Genetics, a component of the BWH Internal Medicine Residency Program, aims to address this problem by training carefully selected BWH Internal Medicine Housestaff in both Internal Medicine and Medical Genetics. The primary goal of these two Programs is to train physicians and physician-scientists who will become leaders in Genomics, and who will help catalyze the introduction of genetics into the care of adult patients.

Program Structure

We believe that the integration of genetics and genomics into contemporary Internal Medicine training requires faculty with a broad range of clinical expertise who can precept and mentor residents in ambulatory settings where patients with genetically-based diseases can be evaluated and managed. In addition to ambulatory experiences, there are also opportunities for inpatient genetics consultation at BWH, MGH and Children’s Hospital. There are also clinical laboratory experiences across the range of diagnostic technologies in cytogenetics, biochemical genetics and molecular genetics. While the Internal Medicine portion of the program is centered at BWH, the Medical Genetics training component takes advantage of the tremendous clinical expertise in genetics that is located throughout the Mass General Brigham System and the Harvard-affiliated Hospitals. The key feature of this combined residency program is the integration of genetics training into the Internal Medicine Residency starting in PGY2. Other key features are the emphasis on genetic diseases of direct interest to internists, and flexibility during the last two years so that residents may pursue additional electives or post-doctoral research in the genetic basis of disease. During PGY2 and 3, residents pursue alternating 3 month blocks of Internal Medicine and Genetic Medicine rotations. Candidates in this program can choose from research mentors who span a very wide spectrum of research endeavors. This Program’s flexibility will allow candidates to use PGY4 and PGY5 to tailor their training toward careers which include clinical research, basic research, or translational research. At the end of the five-year training program, residents are active candidates for certification examinations in both Internal Medicine (ABIM) and Medical Genetics (ABMG), and will in most circumstances have completed a year or more of post-doctoral research training.

The overall program structure is summarized below:

  • PGY 1
    • 12 months of categorical Internal Medicine rotations
  • PGY 2
    • 6 months of Medical Genetics rotations
    • 6 months of Internal Medicine rotations
    • 10 months of Advanced Human Genetics course
    • Longitudinal Genetics Clinic begins, continues through PGY5
  • PGY 3
    • 6 months of Medical Genetics rotations
    • 6 months of Internal Medicine rotations
  • PGY 4
    • Clinical electives in Internal Medicine or Medical Genetics and Research
  • PGY 5
    • Clinical electives in Internal Medicine or Medical Genetics and Research

Research Opportunities

Numerous research opportunities are available to trainees during PGY4 and 5 of the Genetic Medicine Residency Program. We seek to promote rigorous investigation into the genetic basis of human disease, broadly defined. For those who elect basic research, a variety of world-class laboratories exist at Harvard Medical School and the Harvard-affiliated Hospitals. Program faculty will mentor residents and help direct them to the most appropriate laboratory. For clinically oriented research projects that involve human studies or genetic epidemiology, patient cohorts may be identified during Genetics blocks in PGY2 and 3 that become the substrate for focused investigations during PGY4 or 5. Trainees may elect to pursue their research training with mentors who have served as their clinic preceptors during PGY2 and 3.

Faculty and Program Leadership

Over 35 outstanding program faculty from BWH and the other Harvard-affiliated Hospitals, including 5 who are dual certified in Internal Medicine and Medical Genetics. Faculty with expertise in the genetics of specific diseases as well as those with expertise across specific subspecialties of Internal Medicine precept residents in their clinics.

Program Leadership Includes:

Richard Maas, MD, PhD

Chief, BWH Division of Genetics

Joel Katz, MD

Director, BWH Internal Medical Residency Program

Scott Weiss, MD, MS

Scientific Director, Mass General Brigham Center for Personalized Genetic Medicine
Associate Director, Channing Laboratory, BWH

Mira Irons, MD

Associate Chief, Genetics Division, Childrens Hospital Boston
Director, HMS Genetics Training Program

Cynthia Morton, PhD

Director, BWH Cytogenetics Laboratory
Principal Investigator, HMS Genetics Training Grant

Bruce D. Levy, MD, FACP

Academics and Career Development
BWH Internal Medicine Residency Program

Current Residents

The Combined Residency in Genetics and Medicine trains no more than two BWH Internal Medicine residents per year, so that at steady state there may be up to ten trainees in the program.

Sameer Chopra, MD, PhD
Genetic Medical Resident, BWH; Chief Resident, W. Roxbury VA Hosp.
Clinical Fellow in Medicine, HMS
Sameer is a graduate of Harvard University where he studied Biological Anthropology and Neuroscience. He earned his MD, PhD from Vanderbilt where he trained with Dr. Dan Roden. His dissertation was entitled, “Voltage-gated sodium channels are required for cardiac cell fate specification in zebrafish embryos.”

Russell Goodman, MD, PhD
Genetic Medical Resident, BWH
Clinical Fellow in Medicine, HMS
Russell is a graduate of the University of Lethbridge where he studied Biochemistry and Physics for his BSc. He then earned his PhD from the University of Oxford prior to earning his MD from HMS. His PhD thesis involved the use of DNA as an engineering material for nanoscale structures.

Anthony A. Philippakis, MD, PhD
Cardiology Fellow; Genetic Medical Resident, BWH
Clinical Fellow in Medicine, HMS
Anthony is a graduate of Yale and Cambridge Universities where he studied mathematics. He earned his MD, PhD from HMS where he trained with Dr. Martha Bulyk. His dissertation was entitled, “An Integrated Computational Approach for the Determination of Metazoan Cis Regulatory Codes and Cis Regulatory Modules.”

How to Apply

In order to apply, applicants must be accepted into the BWH Internal Medicine Residency and be in the process of completing their categorical internship year (PGY-1). The Combined Residency in Genetics and Medicine begins in PGY-2.

Please see the link below for information on applying to the BWH Internal Medicine Residency. The BWH Internal Medicine Residency only accepts applications through ERAS (Electronic Residency Application Service). Application to the BWH Internal Medicine Residency should be made no later than November 1st.

BWH Internal Medicine Residency Link

Contact Us

Brigham and Women’s Hospital
Division of Genetics
Alumnae Hall
41 Avenue Louis Pasteur
Boston, MA 02115

Victoria Perroni
Program Coordinator
Phone: 617-525-4704
Email: vperroni@research.bwh.harvard.edu